Acute lymphoblastic leukemia in children with associated genetic conditions other than Down syndrome. The AIEOP experience

seven studies on acute lymphoblastic leukemia
(ALL) by the Associazione Italiana Ematologia
Oncologia Pediatrica (AIEOP) to identify patients
with associated genetic disease, other than Down’s
syndrome. Forty-two patients were reported to
have associated genetic conditions that included b-
thalassemia (n=10), ataxia-telangiectasia (n=5),
neurofibromatosis (n=3), Sotos syndrome (n=2)
and other individual conditions. Patients with ataxia-
telangiectasia, all with T-cell ALL, had a higher
frequency of adverse events