Disopyramide-induced neuropathy

Neuropathies are well-known complications of therapy with amiodarone, but other antiarrhythmic drugs are rarely associated with peripheral nervous system side effects.

We describe a patient who developed a severe sensory-motor neuropathy during treatment with disopyramide. The neuropathy was unresponsive to corticosteroids, but improved after withdrawing disopyramide. This is, to our knowledge, the second case of disopyramide-induced neuropathy.