The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo
Academic Article
Publication Date:
2018
abstract:
Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.
Iris type:
01.01 - Articolo in rivista
Keywords:
Inflammation; Innate immunity; Pre-diabetes; Type 2 diabetes; Adult; Benzhydryl Compounds; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Extracellular Traps; Female; Glucosides; Humans; Hypoglycemic Agents; Inflammation; Male; Metformin; Middle Aged; Neutrophils
List of contributors:
Menegazzo, Lisa; Scattolini, Valentina; Cappellari, Roberta; Bonora, Benedetta Maria; Albiero, Mattia; Bortolozzi, Mario; Romanato, Filippo; Ceolotto, Giulio; Vigili de Kreutzeberg, Saula; Avogaro, Angelo; Fadini, Gian Paolo
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