Thrombophilia as a predictor of persistent residual vein thrombosis

To compare the probability of leg vein recanalization between carriers and
non-carriers of thrombophilia after an episode of deep vein thrombosis (DVT) of
the lower extremities, we reviewed the clinical records of 472 patients with
proximal DVT who were diagnosed with thrombophilia, and had long-term ultrasound
scanning. One hundred and thirty-seven patients (29.0%) were carriers of
thrombophilia. After adjusting for age, sex, DVT localization and modality of
presentation, the hazard ratio of vein recanalization in thrombophilic compared
with non-thrombophilic patients was 0.49 (95% CI, 0.38 to 0.63). These findings
suggest that thrombophilia is an independent predictor of persistent residual
vein thrombosis.